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. 2016 Nov;6(6):287.
doi: 10.4172/2161-0460.1000287. Epub 2016 Nov 24.

Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016

M Cacciottolo  1 , T E Morgan  1 , C E Finch  2
Affiliations

Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016

M Cacciottolo et al. J Alzheimers Dis Parkinsonism. 2016 Nov.

Abstract

Cerebral microbleeds (MB) and small vessel disease (SVD) with congophilic arterial angiopathy (CAA) are increasingly recognized as a variable factor in AD cognitive impairments. This commentary on our recent report on sex-ApoE interactions in MBs published this February, briefly explores three aspects of MBs that could not be fully discussed therein: I, A possible gap between the prevalence of MBs as detected by MRI and post mortem analysis; II, The role of hemoglobin-degradation products in amyloid-attributed neurodegenerative changes; and III, Possible assessment of MB by cerebrospinal fluid (CSF) assays for iron-related markers to better screen patient subgroups for AD interventions.

Keywords: Alzheimer disease; CSF heme; Microbleeds; Transgenic mice.

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References

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