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Randomized Controlled Trial
. 2016:2016:9509810.
doi: 10.1155/2016/9509810. Epub 2016 Nov 30.

A Randomized Controlled Trial for the Effectiveness of Aromatherapy in Decreasing Salivary Gland Damage following Radioactive Iodine Therapy for Differentiated Thyroid Cancer

Michihiro Nakayama  1 , Atsutaka Okizaki  1 , Koji Takahashi  1
Affiliations
Randomized Controlled Trial

A Randomized Controlled Trial for the Effectiveness of Aromatherapy in Decreasing Salivary Gland Damage following Radioactive Iodine Therapy for Differentiated Thyroid Cancer

Michihiro Nakayama et al. Biomed Res Int. 2016.

Abstract

Objective. The aim of this study was to investigate effects of aromatherapy in decreasing salivary gland damage for patients undergoing radioactive iodine (RAI) therapy with differentiated thyroid cancer (DTC). Materials and Methods. The subjects were 71 patients with DTC. They were divided into aromatherapy group (group A, n = 35) and a control group (group B, n = 36). We blended 1.0 mL of lemon and 0.5 mL of ginger essential oils. The patients in the inhalation aromatherapy group inhaled this blend oil and those in the control group inhaled distilled water as placebo for 10 min during admission. We statistically compared salivary gland function before and after treatment between groups A and B. Results. In comparison with group B, the rate of change of the accumulation rate was significantly higher in the parotid glands and submandibular glands of group A (P < 0.05). In comparison with group B, a significant increase in rate of secretion change before and after treatment was noted in the bilateral parotid glands in group A (P < 0.05). Conclusion. Because an amelioration of salivary gland function was observed in the present study, our results suggest the efficacy of aromatherapy in the prevention of treatment-related salivary gland disorder. This trial is registered with UMIN Clinical Trial Registry: UMIN000013968.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Figure 1
Figure 1
Regions of interest on the summation image as obtained by dynamic scintigraphy.
Figure 2
Figure 2
Measurement of salivary gland functions by salivary gland scintigraphy.
Figure 3
Figure 3
Comparison of rate of change of maximum accumulation ratio in parotid glands.
Figure 4
Figure 4
Comparison of rate of change of maximum accumulation ratio in submandibular glands.
Figure 5
Figure 5
Comparison of rate of change of washout ratio in parotid glands.
Figure 6
Figure 6
Comparison of rate of change of washout ratio in submandibular glands.
See this image and copyright information in PMC

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