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. 2017 May;29(5):325-328.
doi: 10.1016/j.clon.2016.12.011. Epub 2016 Dec 30.

Thyroid Stimulating Hormone Suppression in the Long-term Follow-up of Differentiated Thyroid Cancer

B Freudenthal  1 , G R Williams  2
Affiliations
Free article

Thyroid Stimulating Hormone Suppression in the Long-term Follow-up of Differentiated Thyroid Cancer

B Freudenthal et al. Clin Oncol (R Coll Radiol). 2017 May.
Free article

Abstract

Differentiated thyroid cancer is the most common form of thyroid cancer and its prognosis is favourable in most cases. Suppression of thyroid stimulating hormone (TSH) by supra-physiological thyroid hormone replacement has been the mainstay of long-term management for over 60 years. However, evidence for a beneficial outcome of TSH suppression is conflicting and intervention must be balanced against adverse effects, particularly affecting the cardiovascular system and skeleton. Here we discuss the role of TSH suppression in the long-term management of differentiated thyroid cancer in the context of risk stratification for disease recurrence and the latest clinical guidelines.

Keywords: Differentiated thyroid cancer; TSH suppression; subclinical thyrotoxicosis.

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