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. 1989;22(3):341-4.

Participation of tumor necrosis factor in the antitumor activity of mycobacterial trehalose dimycolate (cord factor)

C L Silva  1
Affiliations
  • PMID: 2804469

Participation of tumor necrosis factor in the antitumor activity of mycobacterial trehalose dimycolate (cord factor)

C L Silva. Braz J Med Biol Res. 1989.

Abstract

Trehalose dimycolate, a mycobacterial glycolipid also known as cord factor, retains some of the antitumor properties of the intact BCG. Murine macrophages incubated in vitro in the presence of trehalose dimycolate for 20 h at 37 degrees C released a factor which was cytotoxic for the L929 tumor cell line. Anti-tumor necrosis factor (TNF) blocked the cytotoxicity of trehalose dimycolate macrophage supernatant. Therefore the antitumor activity of trehalose dimycolate can be attributed to TNF released in the in vitro assay.

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