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. 1989 Oct 16;499(2):367-70.
doi: 10.1016/0006-8993(89)90786-5.

Allopurinol inhibits uric acid accumulation in the rat brain following focal cerebral ischemia

H Kanemitsu  1 , A Tamura, T Kirino, H Oka, K Sano, T Iwamoto, M Yoshiura, K Iriyama
Affiliations

Allopurinol inhibits uric acid accumulation in the rat brain following focal cerebral ischemia

H Kanemitsu et al. Brain Res. .

Abstract

Uric acid (UA) in the rat brain was measured by HPLC with an electrochemical detector following focal ischemia. At 24 h after the operation, the UA level in the ischemic center was 105.47 +/- 8.39 nmol/g tissue, whereas it was 8.36 +/- 1.86 in the sham-operated group. Allopurinol, xanthine oxidase inhibitor, almost completely inhibited this UA accumulation. These data demonstrate that the UA increase in the ischemic brain is due to the xanthine oxidase reaction.

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