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Editorial
. 2017 Jan 3;43(1):2.
doi: 10.1186/s13052-016-0322-z.

Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children

Mariella Valenzise  1 , Tommaso Aversa  1 , Giuseppina Zirilli  1 , Giuseppina Salzano  1 , Domenico Corica  1 , Simona Santucci  1 , Filippo De Luca  2
Affiliations
Editorial

Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children

Mariella Valenzise et al. Ital J Pediatr. .

Abstract

Aim of this commentary is to report the most recent views about natural history of subclinical hypothyroidism (SH) according to the different etiologies. In children with idiopathic SH the natural evolution is often favourable, with a high percentage of cases reverting to euthyroidism or remaining SH even after a prolonged follow-up. By contrast, the risk of a significant deterioration of thyroid status is distinctly higher in the SH children with Hashimoto's thyroiditis (HT). This risk is even higher in the cases with both HT-related SH and chromosomal abnormalities, such as Turner or Down's syndrome.

Keywords: Chromosomopathies; Down’s syndrome; Hashimoto’s thyroiditis; Thyroid function; Thyroid status; Turner syndrome.

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Figures

Fig. 1
Fig. 1
Prevalence (%) of the main biochemical pictures of thyroid function detected, at the end of a 5-year follow-up, in two groups of children who presented with either idiopathic subclinical hypothyroidism (SH) (Group A) or Hashimoto’s thyroiditis (HT)-related SH (Group B) (according to the results of Reference 18 study)
Fig. 2
Fig. 2
Prevalence (%) of the main biochemical pictures of thyroid function detected, at the end of a 5-year follow-up, in three subgroups of children with Hashimoto’s thyroiditis (HT)-related subclinical hypothyroidism without chromosomopathies (Subgroup B1) or with Turner syndrome (Subgroup B2) or Down’s syndrome (Subgroup B3) (according to the results of Reference 18 study)
See this image and copyright information in PMC

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