Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017;56(1):41-45.
doi: 10.2169/internalmedicine.56.7374. Epub 2017 Jan 1.

Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases

Ayaka Sako  1 , Sung Kwan Bae, Toshifumi Gushima, Junichi Motoshita, Shigemune Bekki, Seigo Abiru, Atsumasa Komori, Shinji Shimoda, Masahiro Ito, Hiroshi Yatsuhashi, Kazuhiro Takahashi
Affiliations
Case Reports

Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases

Ayaka Sako et al. Intern Med. 2017.

Abstract

We herein report two cases of drug-induced liver injury (DILI) due to mosapride. Case 1: A 78-year-old man was admitted with elevated transaminase levels. The cessation of mosapride led to the improvement of elevated liver enzyme levels. Case 2: A 54-year-old man was admitted with jaundice. Mosapride was discontinued immediately, and methylprednisolone was administered for acute liver failure. The patient's data showed improvement, and he was discharged on Day 32. In both cases, mosapride gave a positive response to a drug-induced lymphocyte stimulation test (DLST), and the patient's score based on the criteria for DILI was "highly probable".

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The clinical course of Case 1.
Figure 2.
Figure 2.
Liver biopsy at Day 11 showed collapsed hepatocytes in zone 3 with slight infiltration of the acini by inflammatory cells, including lymphocytes and histiocytes.
Figure 3.
Figure 3.
The clinical course of the Case 2.
Figure 4.
Figure 4.
Laparoscopy at Day 11 showed reddish markings on the surface of the liver.
Figure 5.
Figure 5.
Liver biopsy at Day 11 showed distinct interface hepatitis, bridging necrosis with regenerative micronodules, numerous foci of lobular inflammation, and collapsed hepatocytes.
See this image and copyright information in PMC

References

    1. Ruth M, Hamelin B, Röhss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 12: 35-40, 1998. - PubMed
    1. Tack J. Prokinetics and fundic relaxants in upper functional GI disorders. Curr Opin Pharmacol 8: 690-696, 2008. - PubMed
    1. Kim SH, Naisbitt DJ. Update on advances in research on idiosyncratic drug-induced liver injury. Allergy Asthma Immunol Res 8: 3-11, 2016. - PMC - PubMed
    1. Pharmaceuticals and medical devices safety information [Internet]. [cited 2016 Apr. 5] Available from: http://www1.mhlw.go.jp/kinkyu/iyaku_j/iyaku_j/anzenseijyouhou/291.pdf (in Japanese).
    1. Fontana RJ, Seeff LB, Andrade RJ, et al. . Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop. Hepatology 52: 730-742, 2010. - PMC - PubMed

Publication types