Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016:2016:9612421.
doi: 10.1155/2016/9612421. Epub 2016 Dec 6.

Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies

Junfei Zhu  1 , Bin Guo  2 , Min Fu  1 , Wushuang Guo  1 , Yifang Yuan  1 , He Yuan  1 , Suhan Zhang  3 , Haiyang Yu  4
Affiliations
Review

Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies

Junfei Zhu et al. Dis Markers. 2016.

Abstract

Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The meta-analyses were performed using STATA 12.0. Results. 21 studies were yielded. Significant associations were found under heterozygote comparison and dominant model in studies fulfilling HWE (GC versus GG: OR = 0.690, 95% CI = 0.560-0.849, P = 0.000; CC + GC versus GG: OR = 0.690, 95% CI = 0.568-0.838, P < 0.001); significant associations were found under heterozygote comparison and dominant model in Caucasian studies fulfilling HWE (GC versus GG: OR = 0.752, 95% CI = 0.577-0.980, P = 0.035; CC + GC versus GG: OR = 0.737, 95% CI = 0.576-0.944, P = 0.016); significant associations were found under allele comparison, heterozygote comparison, and dominant model in Brazilian population (C versus G: OR = 0.648, 95% CI = 0.497-0.845, P = 0.001; GC versus GG: OR = 0.621, 95% CI = 0.441-0.876, P = 0.007; CC + GC versus GG: OR = 0.649, 95% CI = 0.470-0.896, P = 0.009). Conclusion. IL-6 174 polymorphism is associated with CP susceptibility. In Brazilian and Caucasian population, IL-6 174 GG genotype plays as a risk factor to CP.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no competing interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
Selection process of the included study.
Figure 2
Figure 2
Heterozygote comparison and dominant model of studies fulfilling HWE. (a) GC versus GG (b) GC + CC versus GG.
Figure 3
Figure 3
Allele comparison, heterozygote comparison, and dominant model of Brazilian subgroup. (a) C versus G; (b) GC + CC versus GG; (c) GC versus GG.
Figure 4
Figure 4
Heterozygote comparison and dominant model of Caucasian studies fulfilling HWE. (a) GC versus GG and (b) GC + CC versus GG.
See this image and copyright information in PMC

References

    1. Chaffee B. W., Weston S. J. Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. Journal of Periodontology. 2010;81(12):1708–1724. doi: 10.1902/jop.2010.100321. - DOI - PMC - PubMed
    1. Page R. C., Offenbacher S., Schroeder H. E., Seymour G. J., Kornman K. S. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontology 2000. 1997;14(1):216–248. doi: 10.1111/j.1600-0757.1997.tb00199.x. - DOI - PubMed
    1. Stabholz A., Soskolne W. A., Shapira L. Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis. Periodontology 2000. 2010;53(1):138–153. doi: 10.1111/j.1600-0757.2010.00340.x. - DOI - PubMed
    1. D'Aiuto F., Parkar M., Brett P. M., Ready D., Tonetti M. S. Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections. Cytokine. 2004;28(1):29–34. doi: 10.1016/j.cyto.2004.06.005. - DOI - PubMed
    1. Ianni M., Bruzzesi G., Pugliese D., et al. Variations in inflammatory genes are associated with periodontitis. Immunity and Ageing. 2013;10(1, article no. 39) doi: 10.1186/1742-4933-10-39. - DOI - PMC - PubMed

LinkOut - more resources