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. 2016 Dec;72(Suppl 1):S59-S61.
doi: 10.1016/j.mjafi.2016.05.002. Epub 2016 Jun 14.

Klebsiella oxytoca: An emerging pathogen?

Lavan Singh  1 , M P Cariappa  2 , Mandeep Kaur  3
Affiliations

Klebsiella oxytoca: An emerging pathogen?

Lavan Singh et al. Med J Armed Forces India. 2016 Dec.

Abstract

Klebsiella oxytoca is emerging as an important bacterial isolate causing hospital-acquired infection in adults and having multiple drug resistance to commonly used antibiotics. We analysed our data to observe the current pattern of drug resistance among K. oxytoca isolated from various samples during the period from January 2012 to March 2014 at a tertiary care hospital. A total of 17,335 samples were processed at the hospital laboratory during this period. Klebsiella was isolated from 654 of these clinical samples. Out of these Klebsiella species, 631 (96.48%) were K. pneumoniae and 23 (3.52%) were K. oxytoca. All the K. oxytoca isolates were sensitive to colistin and tigecyclin. However, these isolates showed 58% resistance to imipenem and meropenem. The resistance to gentamicin, amikacin and ceftriaxone was higher at 72%. Resistance to ciprofloxacin and aztreonam was less (58%). All the samples were from patients admitted to ICUs of a tertiary care centre. The data from our study show an increasing burden of infection caused by this bacterium, which is now gaining access to ICUs. It is recommended that Hospital Infection Control Committees must keep a close watch on the antibiotic pattern of K. oxytoca for better patient care.

Keywords: Antibiotic sensitivity; Emerging pathogen; Klebsiella oxytoca.

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Figures

Fig. 1
Fig. 1
Klebsiella oxytoca (n = 23).
See this image and copyright information in PMC

References

    1. Power J.T., Calder M.A. Pathogenic significance of K. oxytoca in acute respiratory tract infection. Thorax. 1983;38(3):205–208. - PMC - PubMed
    1. Hagiwara S., Murata M., Aoki M., Kaneko M., Oshima K. Septic shock caused by K. oxytoca: an autopsy case and a survival case with driving Extracorporeal Membrane Oxygenation. Hippokratia. 2013;17(2):171–173. - PMC - PubMed
    1. Modi D.J., Patel B.V., Patel M.H. A study of extended spectrum beta lactamases (ESBL) and AmpC beta lactamase producing K. pneumoniae in neonatal intensive care unit at tertiary care hospital, Ahmedabad. Natl J Community Med. 2012;3:523–528.
    1. Jayol A., Poirel L., Villegas M.V., Nordmann P. Modulation of mgrB gene expression as a source of colistin resistance in K. oxytoca. Int J Antimicrob Agents. 2015;46(July (1)):108–110. - PubMed
    1. Sato T., Hara T., Horyama T. Mechanism of resistance and bacterial susceptibility in extended spectrum beta lactamases phenotype Klebsiella pneumoniae and Klebsiella oxytoca isolated between 2000 and 2010 in Japan. J Med Microbiol. 2015;64:538–543. - PubMed