Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov;10(11):FC14-FC16.
doi: 10.7860/JCDR/2016/21743.8881. Epub 2016 Nov 1.

A Pilot Study on the Effect of Angiotensin Receptor Blockers on Platelet Aggregation in Hypertensive Patients- A Prospective Observational Study

Arun Suresh  1 , Narendranath Sanji  2 , Pallavi Mahadeva Kamath  1 , Srinivas Lokikere Devendrappa  3 , Shashikala Gowdara Hanumanthareddy  4 , Imran Maniyar  1 , Suresh Surappla Rudrappa  5
Affiliations

A Pilot Study on the Effect of Angiotensin Receptor Blockers on Platelet Aggregation in Hypertensive Patients- A Prospective Observational Study

Arun Suresh et al. J Clin Diagn Res. 2016 Nov.

Abstract

Introduction: Thrombosis is an invariable component contributing to cardiovascular events in patients with hypertension. One of the risk factors of cardiovascular disease is increased platelet activity. One among the widely used antihypertensive agents are Angiotensin II type 1 Receptor Blockers (ARBs). Even though there are many studies involving antihypertensive agents, their antithrombotic properties remain elusive and not fully characterized.

Aim: To evaluate the anti-aggregatory effect of ARBs on platelets in-vivo.

Materials and methods: A total of 60 subjects were included in this observational pilot study conducted in the medicine out patient department of JJM Hospital, Davanagere, Karnataka, India. Among them, 30 patients with essential hypertension attending Medicine OPD of a tertiary care hospital, who were on ARB for at least one month, were enrolled into study group. The control group consisted of 30 normotensive subjects who were not on any drug affecting platelet function. The Bleeding Time (BT) was evaluated for both the groups using Duke method of BT estimation. Data was analysed using SPSS software version 20. The test group was compared with control group using student's unpaired t-test.

Results: The mean BT of study group was 2.488 minutes ± 0.0361 Standard Error of Mean (SEM) and that of control group was 1.998 minutes ± 0.0362 SEM. The result was statistically significant (p<0.001). The average duration of treatment was 2.933 years.

Conclusion: ARB have antiplatelet activity. Increase in BT in ARB group when compared with that of control group is a reflection of antiplatelet activity.

Keywords: Antiplatelet activity; Bleeding time; Thromboxane A2.

PubMed Disclaimer

References

    1. Yang G. Antiplatelet therapy in patients with hypertension. Journal of Translational Internal Medicine. 2013;1(1):28.
    1. Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW, editors. Principles of pharmacology: the pathophysiologic basis of drug therapy. 3rd ed. Philadelphia (PA): Lippincott Williams and Wilkins; 2012. p. 381.
    1. Braun CA, Anderson CM. Pathophysiology: functional alterations in human health. Baltimore (MD): Lippincott Williams and Wilkins; 2007. p. 351.
    1. Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW, editors. Principles of pharmacology: the pathophysiologic basis of drug therapy. 3rd ed. Philadelphia (PA): Lippincott Williams and Wilkins; 2012. p. 380.
    1. Preston RA, Jy W, Jimenez JJ, Mauro LM, Horstman LL, Valle M, et al. Effects of severe hypertension on endothelial and platelet microparticles. Hypertension. 2003;41:211–17. - PubMed

LinkOut - more resources