Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec 29:11:47.
doi: 10.1186/s13013-016-0107-6. eCollection 2016.

Comparison if the addition of multilevel vertebral augmentation to conventional therapy will improve the outcome of patients with multiple myeloma

Ziad A Audat  1 , Mahmoud H Hajyousef  2 , Mohammad D Fawareh  3 , Khaldoon M Alawneh  2 , Mohannad A Odat  4 , Mohammad M Barbarawi  2 , Ali A Alomari  2 , Rami A Jahmani  2 , Mohammad A Khatatbeh  2 , Mohammed A Assmairan  2
Affiliations

Comparison if the addition of multilevel vertebral augmentation to conventional therapy will improve the outcome of patients with multiple myeloma

Ziad A Audat et al. Scoliosis Spinal Disord. .

Abstract

Background: This was a prospective study to evaluate the effect of multilevel vertebral augmentation in addition to conventional therapy in multiple myeloma patients.

Methods: We treated 27 patients, whom were recently diagnosed to have multiple myeloma by two ways of treatment. Thirteen patients (group I) were treated with conventional therapy and 14 patients (group II) with adding vertebroplasty and kyphoplasty. Patients were evaluated pre-treatment and at half, one, two and 3-years post-treatment by using Oswestry Disability Index (ODI), the Stanford Score (SS) and the Spinal Instability Neoplastic Score (SINS).

Results: Mean values of ODI, SS and SINS were 31.9 (63.8%), 4.3 and 13.8 for group I and 33.2 (66.4%), 4.6 and 12.8 for group II before starting treatment. Group II showed improvement better than group I at all follow-up intervals with best results at first 6 months. P-values at the end of the study were ODI = 0.047, SS = 0.180 and SINS = 0.002. Mortality rates were equal of both groups (four patients of each group).

Conclusion: Adding vertebral augmentation to conventional therapy improves multiple myeloma patients' quality of life, but didn't affect the mortality rate.

Keywords: Chemotherapy; Kyphoplasty; Multiple myeloma; Outcomes; Radiotherapy; Spine; Vertebral augmentation; Vertebroplasty.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Anteroposterior view of thoracic and lumbar spine
Fig. 2
Fig. 2
Lateral view of thoracic spine shows vertebrae compressed fractures and some lytic lesions
Fig. 3
Fig. 3
Lateral view of lumbar spine shows compressed fractures and lytic lesions
Fig. 4
Fig. 4
Sagittal views of thoracic and lumbar spine showed multiple lesions of the spine and fracture of many vertebrae
Fig. 5
Fig. 5
Anteroposterior view of thoracic and lumbar spine with multilevel vertebrae filled with bone cement and lateral small vascular leak
Fig. 6
Fig. 6
Lateral view of whole spine showed multilevel vertebrae was filled with bone cement and intraspinal cement leak
Fig. 7
Fig. 7
Shows Oswestry Disability Index; pre-treatment and at intervals of follow up
Fig. 8
Fig. 8
Shows the Stanford Score; pre-treatment and at intervals of follow up
Fig. 9
Fig. 9
Shows the Spinal Instability Neoplastic Score; pre-treatment and at intervals of follow up
See this image and copyright information in PMC

References

    1. La Maida GA, Sala F, Callea G, et al. Efficacy of unipedicular balloon kyphoplasty for treatment of multiple myeloma vertebral lesions. Asian Spine J. 2011;5:162–168. doi: 10.4184/asj.2011.5.3.162. - DOI - PMC - PubMed
    1. Lecouvet FE, Vande Berg BC, Maldague BE, et al. Vertebral compression fractures in multiple myeloma. Part I. Distribution and appearance at MR imaging. Radiology. 1997;204:195–199. doi: 10.1148/radiology.204.1.9205246. - DOI - PubMed
    1. Dudeney S, Lieberman IH, Reinhardt MK, Hussein M. Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol. 2002;20:2382–2387. doi: 10.1200/JCO.2002.09.097. - DOI - PubMed
    1. Lavanga A, Guarnieri G, Muto M. Medical therapy and multilevel vertebroplasty in osteoporosis: when and why. Neuroradiol J. 2010;23:244–248. doi: 10.1177/197140091002300215. - DOI - PubMed
    1. Lane J, Hong R, Koob J, et al. Kyphoplasty enhances function and structural alignment in multiple myeloma. Clin Orthop Rel Res. 2004;426:49–53. doi: 10.1097/01.blo.0000131642.96984.74. - DOI - PubMed

LinkOut - more resources