Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Nov 11;119(11):1146-1148.
doi: 10.1161/CIRCRESAHA.116.310000.

Biochemical Specificity in Human Cardiac Imaging by 13C Magnetic Resonance Imaging

Craig R Malloy  1 , A Dean Sherry  2
Affiliations
Editorial

Biochemical Specificity in Human Cardiac Imaging by 13C Magnetic Resonance Imaging

Craig R Malloy et al. Circ Res. .
No abstract available

Keywords: MRI; heart metabolism; hyperpolarization; pyruvate; pyruvate dehydrogenase.

PubMed Disclaimer

Figures

Figure
Figure. Schematic of the Hyperpolarization Process (A) and Pyruvate Metabolism in the Heart (B)
[1-13C]pyruvate is mixed with a stable free radical, frozen, and exposed to microwaves to generate hyperpolarized [1-13C]pyruvate. After dissolving with hot water, the solution is rapidly loaded into a syringe for intravenous injection (Panel A). In the heart, [1-13C] pyruvate may undergo transamination to [1-13C]alanine, reduction to [1-13C]lactate or oxidation to 13CO2 and acetyl-CoA. Since the activity of carbonic anhydrase is high in the heart, HP13CO2 is rapidly converted to [13C]bicarbonate.
See this image and copyright information in PMC

Comment on

References

    1. Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ. American Heart Association Council on Basic Cardiovascular Sciences. Assessing Cardiac Metabolism: A Scientific Statement from the American Heart Association. Circ Res. 2016;118:1659–701. PMID: 27012580. - PMC - PubMed
    1. Jeffrey FM, Rajagopal A, Malloy CR, Sherry AD. 13C-NMR: a simple yet comprehensive method for analysis of intermediary metabolism. Trends Biochem Sci. Jan. 1991;16(1):5–10. PMID: 2053137. - PubMed
    1. Bottomley PA, Hardy CJ, Roemer PB, Mueller OM. Proton-decoupled, Overhauser-enhanced, spatially localized carbon-13 spectroscopy in humans. Magn Reson Med. 1989;12:348–63. PMID: 2560801. - PubMed
    1. Cunningham CH, Lau JY, Chen AP, Geraghty BJ, Perks WJ, Roifman I, Wright GA, Connelly KA. Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience. Circ Res. 2016 Sep 15; PMID: 27635086. - PMC - PubMed
    1. Abragam A, Goldman M. Principles of Dynamic Nuclear Polarization. Reports on Progress in Physics. 1978;41:395–467.