A PoTENtial Antidote: A Prohemostatic Factor Xa Variant for Reversal of Direct Oral Anticoagulants

Affiliations

¹ From the Departments of Medicine (J.C.F., J.I.W.) and Biochemistry and Biomedical Sciences (J.I.W.) and The Thrombosis and Atherosclerosis Research Institute (J.C.F., J.I.W.), McMaster University, Hamilton, ON, Canada.
² From the Departments of Medicine (J.C.F., J.I.W.) and Biochemistry and Biomedical Sciences (J.I.W.) and The Thrombosis and Atherosclerosis Research Institute (J.C.F., J.I.W.), McMaster University, Hamilton, ON, Canada. weitzj@taari.ca.

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James C Fredenburgh et al. Circ Res. 2016.

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. 2016 Nov 11;119(11):1157-1160.

doi: 10.1161/CIRCRESAHA.116.309820.

¹ From the Departments of Medicine (J.C.F., J.I.W.) and Biochemistry and Biomedical Sciences (J.I.W.) and The Thrombosis and Atherosclerosis Research Institute (J.C.F., J.I.W.), McMaster University, Hamilton, ON, Canada.
² From the Departments of Medicine (J.C.F., J.I.W.) and Biochemistry and Biomedical Sciences (J.I.W.) and The Thrombosis and Atherosclerosis Research Institute (J.C.F., J.I.W.), McMaster University, Hamilton, ON, Canada. weitzj@taari.ca.

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A rapid pro-hemostatic approach to overcome direct oral anticoagulants.
Thalji NK, Ivanciu L, Davidson R, Gimotty PA, Krishnaswamy S, Camire RM. Thalji NK, et al. Nat Med. 2016 Aug;22(8):924-32. doi: 10.1038/nm.4149. Epub 2016 Jul 25. Nat Med. 2016. PMID: 27455511