Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Feb;18(1):10-16.
doi: 10.1111/pedi.12473.

Metformin; a review of its history and future: from lilac to longevity

Inas Thomas  1 , Brigid Gregg  1
Affiliations
Free article
Review

Metformin; a review of its history and future: from lilac to longevity

Inas Thomas et al. Pediatr Diabetes. 2017 Feb.
Free article

Abstract

Metformin is a widely prescribed medication that has been used to treat children with type 2 diabetes in the United States for the past 15 years. Metformin now has a variety of clinical applications in pediatrics, and its potential clinical uses continue to expand. In addition to reviewing the current understanding of its mechanisms of action including the newly discovered effects on the gastrointestinal tract, we will also discuss current clinical uses in pediatrics, including in type 1 diabetes. Finally, we examine the existing state of monitoring for metformin efficacy and side effects and discuss prospective future clinical uses.

Keywords: diabetes; mechanisms; metformin; pediatrics.

PubMed Disclaimer