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. 2017 Feb 23;61(3):e01954-16.
doi: 10.1128/AAC.01954-16. Print 2017 Mar.

Plasmids of Distinct IncK Lineages Show Compatible Phenotypes

Marta Rozwandowicz  1 , Michael S M Brouwer  2 , Aldert L Zomer  1 , Alex Bossers  2 , Frank Harders  2 , Dik J Mevius  1   2 , Jaap A Wagenaar  1   2 , Joost Hordijk  3
Affiliations

Plasmids of Distinct IncK Lineages Show Compatible Phenotypes

Marta Rozwandowicz et al. Antimicrob Agents Chemother. .

Abstract

IncK plasmids are some of the main carriers of blaCTX-M-14 and blaCMY-2 genes and show high similarity to other plasmids belonging to the I complex, including IncB/O plasmids. Here, we studied the phylogenetic relationship of 37 newly sequenced IncK and IncB/O plasmids. We show that IncK plasmids can be divided into two compatible lineages named IncK1 and IncK2.

Keywords: IncK; incompatibility; plasmid.

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Figures

FIG 1
FIG 1
Phylogenetic tree of IncK and IncB/O plasmids.
FIG 2
FIG 2
Comparison of the IncK1 and IncK2 plasmid sequences (A) with an additional focus on the highest variable region in the plasmid scaffolds (B). Asterisks indicate partial gene sequences.
See this image and copyright information in PMC

References

    1. Hordijk J, Wagenaar JA, Kant A, van Essen-Zandbergen A, Dierikx C, Veldman K, Wit B, Mevius D. 2013. Cross-sectional study on prevalence and molecular characteristics of plasmid mediated ESBL/AmpC-producing Escherichia coli isolated from veal calves at slaughter. PLoS One 8:e65681. doi:10.1371/journal.pone.0065681. - DOI - PMC - PubMed
    1. Hordijk J, Mevius DJ, Kant A, Bos ME, Graveland H, Bosman AB, Hartskeerl CM, Heederik DJ, Wagenaar JA. 2013. Within-farm dynamics of ESBL/AmpC-producing Escherichia coli in veal calves: a longitudinal approach. J Antimicrob Chemother 68:2468–2476. doi:10.1093/jac/dkt219. - DOI - PubMed
    1. Stokes MO, Cottell JL, Piddock LJ, Wu G, Wootton M, Mevius DJ, Randall LP, Teale CJ, Fielder MD, Coldham NG. 2012. Detection and characterization of pCT-like plasmid vectors for blaCTX-M-14 in Escherichia coli isolates from humans, turkeys and cattle in England and Wales. J Antimicrob Chemother 67:1639–1644. doi:10.1093/jac/dks126. - DOI - PubMed
    1. Valverde A, Canton R, Garcillan-Barcia MP, Novais A, Galan JC, Alvarado A, de la Cruz F, Baquero F, Coque TM. 2009. Spread of blaCTX-M-14 is driven mainly by IncK plasmids disseminated among Escherichia coli phylogroups A, B1, and D in Spain. Antimicrob Agents Chemother 53:5204–5212. doi:10.1128/AAC.01706-08. - DOI - PMC - PubMed
    1. Dhanji H, Khan P, Cottell JL, Piddock LJ, Zhang J, Livermore DM, Woodford N. 2012. Dissemination of pCT-like IncK plasmids harboring CTX-M-14 extended-spectrum beta-lactamase among clinical Escherichia coli isolates in the United Kingdom. Antimicrob Agents Chemother 56:3376–3377. doi:10.1128/AAC.00313-12. - DOI - PMC - PubMed

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