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Review
. 2016 Dec 22:11:65-82.
doi: 10.2147/DDDT.S84667. eCollection 2017.

Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections

Olivia Ferrández  1 , Olatz Urbina  2 , Santiago Grau  3
Affiliations
Review

Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections

Olivia Ferrández et al. Drug Des Devel Ther. .

Abstract

Tedizolid phosphate has high activity against the Gram-positive microorganisms mainly involved in acute bacterial skin and skin structure infections, such as strains of Staphylococcus aureus (including methicillin-resistant S. aureus strains and methicillin-sensitive S. aureus strains), Streptococcus pyogenes, Streptococcus agalactiae, the Streptococcus anginosus group, and Enterococcus faecalis, including those with some mechanism of resistance limiting the use of linezolid. The area under the curve for time 0-24 hours/minimum inhibitory concentration (MIC) pharmacodynamic ratio has shown the best correlation with the efficacy of tedizolid, versus the time above MIC ratio and the maximum drug concentration/minimum inhibitory concentration ratio. Administration of this antibiotic for 6 days has shown its noninferiority versus administration of linezolid for 10 days in patients with skin and skin structure infections enrolled in two Phase III studies (ESTABLISH-1 and ESTABLISH-2). Tedizolid's more favorable safety profile and dosage regimen, which allow once-daily administration, versus linezolid, position it as a good therapeutic alternative. However, whether or not the greater economic cost associated with this antibiotic is offset by its shorter treatment duration and possibility of oral administration in routine clinical practice has yet to be clarified.

Keywords: acute bacterial skin and skin structure infections; linezolid resistance; oxazolidinone; tedizolid; tedizolid phosphate.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Structure–activity differences between tedizolid and linezolid.
See this image and copyright information in PMC

References

    1. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Guidance for Industry Acute Bacterial Skin and Skin Structure Infections: Developing Drugs for Treatment. Silver Spring, MD: US Food and Drug Administration; 2013. [Accessed May 1, 2016]. Available from: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformati....
    1. Pallin DJ, Egan DJ, Pelletier AJ, Espinola JA, Hooper DC, Camargo CA., Jr Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus. Ann Emerg Med. 2008;51(3):291–298. - PubMed
    1. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant Saureus infections among patients in the emergency department. N Engl J Med. 2006;355(7):666–674. - PubMed
    1. Talan DA, Krishnadasan A, Gorwitz RJ, et al. Comparison of Staphylococcus aureus from skin and soft-tissue infections in US emergency department patients, 2004 and 2008. Clin Infect Dis. 2011;53(2):144–149. - PubMed
    1. Moran GJ, Amii RN, Abrahamian FM, Talan DA. Methicillin-resistant Staphylococcus aureus in community-acquired skin infections. Emerg Infect Dis. 2005;11(6):928–930. - PMC - PubMed

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