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Review
. 2016 Dec 20:10:1-6.
doi: 10.2147/IJGM.S119301. eCollection 2017.

Hepatitis C in Egypt - past, present, and future

Ahmed Elgharably  1 , Asmaa I Gomaa  2 , Mary Me Crossey  1 , Peter J Norsworthy  3 , Imam Waked  2 , Simon D Taylor-Robinson  3
Affiliations
Review

Hepatitis C in Egypt - past, present, and future

Ahmed Elgharably et al. Int J Gen Med. .

Abstract

Hepatitis C viral infection is endemic in Egypt with the highest prevalence rate in the world. It is widely accepted that the implementation of mass population antischistosomal treatment involving administration of tartar emetic injections (from 1950s to 1980s) led to widespread infection. What is less well known, however, is that these schemes were implemented by the Egyptian Ministry of Health on the advice of the World Health Organization. There has been a spectrum of treatments to target the public health disaster represented by the hepatitis C problem in Egypt: from the use of PEGylated interferon to the recent use of direct acting antiviral drugs. Some new treatments have shown >90% efficacy. However, cost is a key barrier to access these new medicines. This is coupled with a growing population, limited resources, and a lack of infection control practices which means Egypt still faces significant disease control issues today.

Keywords: Egypt; hepatitis C; schistosomiasis.

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Conflict of interest statement

MMEC is supported by a Fellowship from the Sir Halley Stewart Trust (Cambridge, UK). MMEC and SDT-R hold grants from the United Kingdom Medical Research Council. AIG was supported by a doctorate grant from the Egyptian Ministry of Higher Education. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
HCV: model structure and genome organization. Notes: (A) Model structure of HCV. (B) Proteins encoded by the HCV genome. Expert review in Molecular Medicine © 2003 Cambridge University Press. Abbreviations: HCV, hepatitis C viral; IFN, interferon; NTR, nontranslated RNA.
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References

    1. El-Zanaty F, Way A. Egypt Demographic and Health Survey 2008. Cairo, Egypt: Ministry of Health, El-Zanaty and Associates, and Macro International; 2009. p. 431.
    1. Frank C, Mohamed M, Strickland GT, et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet. 2000;355(9207):887–891. - PubMed
    1. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5(9):558–567. - PubMed
    1. Wanis H. HCV treatment in Egypt – why cost remains a challenge? Cairo, Egypt: Egyptian initiative for personal rights [serial on the Internet]; 2014. [Accessed June 16, 2016]. pp. 1–4. Available from: http://www.eipr.org/sites/default/files/pressreleases/pdf/hcv_treatment_....
    1. Waked I, Doss W, El-Sayed M, et al. The current and future disease burden of chronic hepatitis C virus infection in Egypt. Arab J Gastroenterol. 2014;15(2):45–52. - PubMed