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Review
. 2016 Nov 30;7(1-3):1-7.
doi: 10.1016/j.jccw.2016.10.001. eCollection 2015 Dec.

Novel Insights on Understanding of Keloid Scar: Article Review

Walid Mari  1 , Sami G Alsabri  1 , Najib Tabal  1 , Sara Younes  1 , Abdulamagid Sherif  1 , Richard Simman  1
Affiliations
Review

Novel Insights on Understanding of Keloid Scar: Article Review

Walid Mari et al. J Am Coll Clin Wound Spec. .

Abstract

Keloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars include combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment. In this review, PubMed, clinical key and Wright State Library web site have been used to investigate any update regarding Keloid disease. We used Keloid, scar formation, hypertrophic scar and collagen as key words. More than 40 articles have been reviewed. This paper reviews literature about keloid scar formation mechanism, the most recent therapeutic options including the ones under research.

Keywords: Collagen; Hypertrophic scar; Keloid; Scar formation.

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