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. 2017 Jan;116(3):389-397.
doi: 10.1038/bjc.2016.421. Epub 2017 Jan 5.

The impact of age on complications, survival, and cause of death following colon cancer surgery

Christopher T Aquina  1 , Supriya G Mohile  2 , Mohamedtaki A Tejani  2 , Adan Z Becerra  1 , Zhaomin Xu  1 , Bradley J Hensley  1 , Reza Arsalani-Zadeh  1 , Francis P Boscoe  3 , Maria J Schymura  3 , Katia Noyes  1 , John Rt Monson  1   4 , Fergal J Fleming  1
Affiliations

The impact of age on complications, survival, and cause of death following colon cancer surgery

Christopher T Aquina et al. Br J Cancer. 2017 Jan.

Abstract

Background: Given scarce data regarding the relationship among age, complications, and survival beyond the 30-day postoperative period for oncology patients in the United States, this study identified age-related differences in complications and the rate and cause of 1-year mortality following colon cancer surgery.

Methods: The NY State Cancer Registry and Statewide Planning and Research Cooperative System identified stage I-III colon cancer resections (2004-2011). Multivariable logistic regression and survival analyses assessed the relationship among age (<65, 65-74, ⩾75), complications, 1-year survival, and cause of death.

Results: Among 24 426 patients surviving >30 days, 1-year mortality was 8.5%. Older age groups had higher complication rates, and older age and complications were independently associated with 1-year mortality (P<0.0001). Increasing age was associated with a decrease in the proportion of deaths from colon cancer with a concomitant increase in the proportion of deaths from cardiovascular disease. Older age and sepsis were independently associated with higher risk of colon cancer-specific death (65-74: HR=1.59, 95% CI=1.26-2.00; ⩾75: HR=2.57, 95% CI=2.09-3.16; sepsis: HR=2.58, 95% CI=2.13-3.11) and cardiovascular disease-specific death (65-74: HR=3.72, 95% CI=2.29-6.05; ⩾75: HR=7.02, 95% CI=4.44-11.10; sepsis: HR=2.33, 95% CI=1.81-2.99).

Conclusions: Older age and sepsis are associated with higher 1-year overall, cancer-specific, and cardiovascular-specific mortality, highlighting the importance of geriatric assessment, multidisciplinary care, and cardiovascular optimisation for older patients and those with infectious complications.

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Conflict of interest statement

FJF received personal fees from UpToDate unrelated to the current work. The other authors have no conflicts of interest to report. Oral presentation at 2016 American Society of Clinical Oncology Annual Meeting, Chicago, IL, 6 June 2016.

Figures

Figure 1
Figure 1
Bar graph depicting 1-year overall mortality rates by (A) postoperative complication status (yes/no) and (B) sepsis status (yes/no) stratified by age group (<65, 65–74, and ⩾75 years old).
See this image and copyright information in PMC

References

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