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. 2017 Feb 7;8(6):10523-10530.
doi: 10.18632/oncotarget.14451.

Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer

Yifei Wu  1 , Mengdan Yan  1   2 , Jing Li  1   2 , Jingjie Li  1   2 , Zhengshuai Chen  1   2 , Peng Chen  1   2   3 , Bin Li  1   2 , Fulin Chen  1 , Tianbo Jin  1   2 , Chao Chen  1
Affiliations

Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer

Yifei Wu et al. Oncotarget. .

Abstract

Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi'an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the "Trs10069690Ars2242652", "Trs10069690Grs2242652" haplotypes were associated with an increased risk of esophageal cancer, while the and "Crs10069690Grs2242652" haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer.

Keywords: SNP; TERT; esophageal cancer; northwest Chinese population; susceptibility.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Linkage disequilibrium patterns for four TERT SNPs
See this image and copyright information in PMC

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