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Meta-Analysis
. 2017 Jan 6;12(1):e0169076.
doi: 10.1371/journal.pone.0169076. eCollection 2017.

Patterns of Gray Matter Abnormalities in Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies

Guo Bin  1 , Tianfu Wang  1 , Hongwu Zeng  2 , Xiaoming He  3 , Feng Li  4 , Jian Zhang  5 , Bingsheng Huang  1
Affiliations
Meta-Analysis

Patterns of Gray Matter Abnormalities in Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies

Guo Bin et al. PLoS One. .

Abstract

Objective: We aimed to identify the consistent regions of gray matter volume (GMV) abnormalities in idiopathic generalized epilepsy (IGE), and to study the difference of GMV abnormalities among IGE subsyndromes by applying activation likelihood estimation (ALE) meta-analysis.

Methods: A systematic review of VBM studies on GMV of patients with absence epilepsy (AE), juvenile myoclonic epilepsy (JME), IGE and controls indexed in PubMed and ScienceDirect from January 1999 to June 2016 was conducted. A total of 12 IGE studies, including 7 JME and 3 AE studies, were selected. Meta-analysis was performed on these studies by using the pooled and within-subtypes analysis (www.brainmap.org). Based on the above results, between-subtypes contrast analysis was carried out to detect the abnormal GMV regions common in and unique to each subtype as well.

Results: IGE demonstrated significant GMV increase in right ventral lateral nucleus (VL) and right medial frontal gyrus, and significant GMV decrease in bilateral pulvinar. For JME, significant GMV increase was seen in right medial frontal gyrus, right anterior cingulate cortex (ACC), while significant GMV decrease was found in right pulvinar. In AE, the most significant GMV increase was found in right VL, and slight GMV reduction was seen in right medial dorsal nucleus, right subcallosal gyrus, left caudate and left precuneus. No overlapped and unique regions with significant GMV abnormalities were found between JME and AE.

Significance: This meta-analysis demonstrated that thalamo-frontal network was a structure with significant GMV abnormality in IGE, and the IGE subsyndromes showed different GMV abnormal regions. These observations may provide instructions on the clinical diagnosis of IGE.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of studies included in the current review.
Fig 2
Fig 2. Summary of studies included in the ALE meta-analysis.
ALE, activation likelihood estimation; IGE, idiopathic generalized epilepsy; VBM, voxel-based morphometry; HC, healthy controls; SD, standard deviation; NA, not available;* Median age.
Fig 3
Fig 3. ALE results of gray matter volume comparison in IGE subsyndromes.
ALE, activation likelihood estimation; IGE, idiopathic generalized epilepsy; JME, juvenile myoclonic epilepsy; AE, absence epilepsy; MNI, montreal neurological institute.
Fig 4
Fig 4. Results of ALE meta-analysis with GMV increase.
Significant GMV increase was found in: for IGE, right ventral lateral nucleus and right medial frontal gyrus; for JME, right medial frontal gyrus and right anterior cingulate; and for AE, right ventral lateral nucleus. IGE, idiopathic generalized epilepsy; JME, juvenile myoclonic epilepsy; AE, absence epilepsy; ALE, activation likelihood estimation; GMV, gray matter volume.
Fig 5
Fig 5. Results of ALE meta-analysis with GMV decrease.
Significant GMV decrease was found in: for IGE, bilateral pulvinar; for JME, right pulvinar; and for AE, right medial dorsal nucleus, right subcallosal gyrus, left caudate and left precuneus. IGE, idiopathic generalized epilepsy; JME, juvenile myoclonic epilepsy; AE, absence epilepsy; ALE, activation likelihood estimation; GMV, gray matter volume.
See this image and copyright information in PMC

References

    1. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30: 389–399. - PubMed
    1. Zifkin B, Andermann E., Andermann F. Mechanisms, genetics, and pathogenesis of juvenile myoclonic epilepsy. Curr Opin Neurol. 2005;18: 147–153. - PubMed
    1. Koutroumanidis M, Aggelakis K, Panayiotopoulos CP. Idiopathic epilepsy with generalized tonic–clonic seizures only versus idiopathic epilepsy with phantom absences and generalized tonic–clonic seizures: One or two syndromes? Epilepsia. 2008;49: 2050–2062. 10.1111/j.1528-1167.2008.01702.x - DOI - PubMed
    1. Suthida Y, A Simon, Carla M, Mark R N, Mark A K, Samuel F B. EEG in adult-onset idiopathic generalized epilepsy. Epilepsia. 2003;44: 252–256. - PubMed
    1. Panayiotopoulos CP. Idiopathic generalized epilepsies In: Panayiotopoulos C.P. (Ed.), A Clinical Guide to Epileptic Syndromes and their Treatment. Bladon Medical Publishing, Oxfordshire: 2002;115–160.

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