Seq-ing Markers of Midbrain Dopamine Neurons
- PMID: 28061349
- DOI: 10.1016/j.stem.2016.12.014
Seq-ing Markers of Midbrain Dopamine Neurons
Abstract
Transplantation of human pluripotent stem cell-derived dopaminergic neurons is a promising approach to treating Parkinson's disease. In this issue of Cell Stem Cell, Kee et al. (2017) and Kirkeby et al. (2017) identify specific markers of midbrain dopaminergic progenitors to improve their derivation and predict dopamine neuron content after engraftment.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.Cell Stem Cell. 2017 Jan 5;20(1):135-148. doi: 10.1016/j.stem.2016.09.004. Epub 2016 Oct 27. Cell Stem Cell. 2017. PMID: 28094017 Free PMC article.
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Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.Cell Stem Cell. 2017 Jan 5;20(1):29-40. doi: 10.1016/j.stem.2016.10.003. Epub 2016 Oct 27. Cell Stem Cell. 2017. PMID: 28094018
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