Hacking the Matrix
- PMID: 28061355
- PMCID: PMC6334287
- DOI: 10.1016/j.stem.2016.12.010
Hacking the Matrix
Abstract
Recently in Nature, Gjorevski et al. (2016) describe a fully defined synthetic hydrogel that mimics the extracellular matrix to support in vitro growth of intestinal stem cells and organoids. The hydrogel allows exquisite control over the chemical and physical in vitro niche and enables identification of regulatory properties of the matrix.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Designer matrices for intestinal stem cell and organoid culture.Nature. 2016 Nov 24;539(7630):560-564. doi: 10.1038/nature20168. Epub 2016 Nov 16. Nature. 2016. PMID: 27851739
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- Gjorevski N, Sachs N, Manfrin A, Giger S, Bragina ME, Ordóñez-Morán P, Clevers H, and Lutolf MP (2016). Nature 539, 560–564. - PubMed
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