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Comment
. 2017 Jan;7(1):17-19.
doi: 10.1158/2159-8290.CD-16-1308.

Repurposing Antiestrogens for Tumor Immunotherapy

Thomas Welte  1 , Xiang H-F Zhang  1 , Jeffrey M Rosen  2
Affiliations
Comment

Repurposing Antiestrogens for Tumor Immunotherapy

Thomas Welte et al. Cancer Discov. 2017 Jan.

Abstract

Svoronos and colleagues observed estrogen receptor alpha-positive cells in the tumor stroma of patients with ovarian cancer that appeared to be independent of both the tumor's estrogen receptor status and tumor type. These cells were identified as immunosuppressive myeloid-derived suppressor cells (MDSC) and could be targeted by antiestrogen therapy, thereby leading to the hypothesis that endocrine therapy when combined with immunotherapy may provide a potential therapeutic benefit by helping to reduce immunosuppressive MDSCs. Cancer Discov; 7(1); 17-9. ©2017 AACRSee related article by Svoronos et al., 72.

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Conflict of interest statement

The authors disclose no potential conflicts of interest.

Comment on

References

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