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Review
. 2016 Dec;31(6):472-479.
doi: 10.1007/s12250-016-3924-0. Epub 2016 Dec 28.

The role of microRNAs in hepatocyte metabolism and hepatitis B virus replication

Wanyu Deng  1   2 , Mengji Lu  3
Affiliations
Review

The role of microRNAs in hepatocyte metabolism and hepatitis B virus replication

Wanyu Deng et al. Virol Sin. 2016 Dec.

Abstract

Though efficient vaccines against hepatitis B virus (HBV) and antiviral therapies are available, chronic HBV infection is still a global health problem. The process of HBV infection and HBV life cycle are extensively studied in last decades, however, the mechanisms of HBV-induced alterations of host cell metabolisms and host factors involved in modulating of viral replication are not fully understood. Thus, it is an important issue to examine these specific HBV-host interactions for development of novel strategies for antiviral therapies. Recently, microRNAs (miRNAs), a class of post-transcriptional regulatory small RNA, seem to be the relevant fine tuning factors of various cellular activities and pathways, including cell growth, metabolism, and viral replication. In this review, we summarize the up to date knowledge concerning the virus-host interactions and emphasizing on the role of miRNAs in regulation of HBV replication and host cell metabolism.

Keywords: HBV replication; cell metabolism; hepatocytes; microRNA; transcription factors.

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