Review
doi: 10.1016/j.nut.2016.09.010.
Epub 2016 Oct 1.
Tackling guanidinoacetic acid for advanced cellular bioenergetics
Affiliations
- PMID: 28063512
- DOI: 10.1016/j.nut.2016.09.010
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Review
Tackling guanidinoacetic acid for advanced cellular bioenergetics
Nutrition.
2017 Feb.
Abstract
Tissues with high-energy output, such as the brain and skeletal muscle, suffer the most from impaired or depleted energy levels, with innovative nutritional approaches needed to effectively tackle metabolic deficits in bioenergetics. Here, we highlight the role of guanidinoacetic acid in the control and provision of cellular energy by its interaction with cellular transporters for taurine (SLC6 A6) and γ-aminobutyric acid (SLC6 A13), previously dismissed as "untargetable" carriers by other bioenergetics therapeutics.
Keywords: Bioenergetics; Creatine; Guanidinoacetic acid; SLC6 A13; SLC6 A6.
Copyright © 2016 Elsevier Inc. All rights reserved.
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