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. 2017 May 1;56(5):736-744.
doi: 10.1093/rheumatology/kew468.

Rheumatoid arthritis is getting less frequent-results of a nationwide population-based cohort study

Abhishek Abhishek  1 , Michael Doherty  1 , Chang-Fu Kuo  1 , Christian D Mallen  2 , Weiya Zhang  1 , Matthew J Grainge  3
Affiliations

Rheumatoid arthritis is getting less frequent-results of a nationwide population-based cohort study

Abhishek Abhishek et al. Rheumatology (Oxford). .

Abstract

Objectives: The objectives of this study were to examine changes in the incidence and prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in the incidence and prevalence of RA in the UK.

Methods: This was a primary care-based prospective cohort study. People contributing acceptable data to Clinical Practice Research Datalink between 1 January 1990 and 31 December 2014 were included. Read codes were used to identify RA cases ⩾18 years of age. The prevalence and incidence rates for each year were standardized to the 2014 population and the regional incidence and prevalence of RA for the year 2014 were standardized to the overall population.

Results: The incidence and prevalence of RA was 3.81/10 000 person-years and 0.67%, respectively, in 2014. The annual incidence of RA decreased by 1.6% (95% CI 0.8, 2.5) between 1990 and 2014, with significant joinpoints at 1994 and 2002. The prevalence of RA increased by 3.7%/year (95% CI 3.2, 4.1) from 1990 to 2005 and decreased by 1.1%/year (95% CI 2.0, 0.2) between 2005 and 2014. There were significant differences in the occurrence of RA throughout different regions of the UK, with the highest incidence in East Midlands, Yorkshire and Humber and the highest prevalence in North East, Yorkshire and Humber.

Conclusion: The incidence of RA is decreasing, with a reduction in prevalence in recent years. There is significant geographic variation in the occurrence of RA in the UK. Further research is required to identify the reasons underlying this phenomenon so that public health interventions can be designed to further reduce the incidence of RA.

Keywords: geographic variation; incidence; prevalence; rheumatoid arthritis.

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Figures

F<sc>ig</sc>. 1
Fig. 1
Increasing prevalence and incidence of RA with age (A) Increasing prevalence of RA with age. (B) Increasing incidence of RA with age.
F<sc>ig</sc>. 2
Fig. 2
Mid-year prevalence of RA in the UK, 1990–2014 Data given as prevalence and 95% CI. Black line, prevalence; red line, upper 95% CI estimates; blue line, lower 95% CI estimates.
F<sc>ig</sc>. 3
Fig. 3
Annual incidence of RA in the UK, 1990–2014 Data given as incidence and 95% CI. Black line, prevalence; red line, upper 95% CI estimates; blue line, lower 95% CI estimates.
See this image and copyright information in PMC

References

    1. Silman AJ, Pearson JE.. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res 2002;4(Suppl 3): S265–72. - PMC - PubMed
    1. Alamanos Y, Voulgari PV, Drosos AA.. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review. Semin Arthritis Rheum 2006;36:182–8. - PubMed
    1. Entezami P, Fox DA, Clapham PJ, Chung KC.. Historical perspective on the etiology of rheumatoid arthritis. Hand Clin 2011;27:1–10. - PMC - PubMed
    1. Massó González EL, Johansson S, Wallander M-A, García Rodríguez LA.. Trends in the prevalence and incidence of diabetes in the UK: 1996–2005. J Epidemiol Community Health 2009;63:332–6. - PubMed
    1. James PT, Rigby N, Leach R, Force IOT.. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil 2004; 11:3–8. - PubMed

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