doi: 10.1016/0014-4800(89)90010-5.
Variations of serum lipoproteins during cell proliferation induced by lead nitrate
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- PMID: 2806472
- DOI: 10.1016/0014-4800(89)90010-5
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Variations of serum lipoproteins during cell proliferation induced by lead nitrate
Exp Mol Pathol.
1989 Oct.
Abstract
In the present study serum lipoproteins were investigated during cell proliferation induced by a potent mitogen, lead nitrate. A strong decrease in HDL2 and a concomitant increase in HDL3 were observed in lead-treated rats. The recovery of normal lipoprotein pattern took place together with the regression of hyperplastic process. Since a decrease in HDL also occurs under other conditions of cell growth, we hypothesize that a decrease in HDL, mainly in HDL2 subfraction, may represent a generalized phenomenon related to massive cell proliferation.
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