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. 1989 Oct;51(2):97-102.
doi: 10.1016/0014-4800(89)90010-5.

Variations of serum lipoproteins during cell proliferation induced by lead nitrate

S Dessí  1 , B Batetta, A Carrucciu, D Pulisci, S Laconi, A M Fadda, C Anchisi, P Pani
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Variations of serum lipoproteins during cell proliferation induced by lead nitrate

S Dessí et al. Exp Mol Pathol. 1989 Oct.

Abstract

In the present study serum lipoproteins were investigated during cell proliferation induced by a potent mitogen, lead nitrate. A strong decrease in HDL2 and a concomitant increase in HDL3 were observed in lead-treated rats. The recovery of normal lipoprotein pattern took place together with the regression of hyperplastic process. Since a decrease in HDL also occurs under other conditions of cell growth, we hypothesize that a decrease in HDL, mainly in HDL2 subfraction, may represent a generalized phenomenon related to massive cell proliferation.

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