[Effect of foridon on the blood supply of the cat brain in health and in intracerebral hemorrhage]

Abstract

In experiments on anesthetized cats, foridone (1 and 3 micrograms/kg/min intravenously) was found to increase cerebral blood flow by 6-26% with a moderate decrease of systemic arterial blood pressure indicating that the drug possessed properties with respect to a selective cerebral vasodilatator. Phenygidine (0.3-3 micrograms/kg/min) did not exhibit such a property. Intravenous administration of foridone (1 microgram/kg/min) to cats one day after intracerebral hemorrhage produced a significant improvement of blood supply to the brain, glucose utilization by the brain, a moderate increase of oxygen consumption.