Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Dec 23:7:647.
doi: 10.3389/fphys.2016.00647. eCollection 2016.

Commentary: Reciprocal Modulation of IK1-INa Extends Excitability in Cardiac Ventricular Cells

Birgit Goversen  1 , Teun P de Boer  1 , Marcel A G van der Heyden  1
Affiliations
Comment

Commentary: Reciprocal Modulation of IK1-INa Extends Excitability in Cardiac Ventricular Cells

Birgit Goversen et al. Front Physiol. .
No abstract available

Keywords: KIR2.1; Nav1.5; arrhythmia; induced pluripotent stem cells; inward rectifier current; reciprocal modulation; sodium current.

PubMed Disclaimer

Comment on

References

    1. Ambrosini E., Sicca F., Brignone M. S., D'Adamo M. C., Napolitano C., Servettini I., et al. . (2014). Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype. Hum. Mol. Genet. 23, 4875–4886. 10.1093/hmg/ddu201 - DOI - PMC - PubMed
    1. De Boer T. P., Houtman M. J., Compier M., Van der Heyden M. A. G. (2010). The mammalian KIR2.x inward rectifier ion channel family: expression pattern and pathophysiology. Acta Physiol. (Oxf). 199, 243–256. 10.1111/j.1748-1716.2010.02108.x - DOI - PubMed
    1. Jonsson M. K. B., Vos M. A., Mirams G. R., Duker G., Sartipy P., De Boer T. P., et al. . (2012). Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. J. Mol. Cell. Cardiol. 52, 998–1008. 10.1016/j.yjmcc.2012.02.002 - DOI - PubMed
    1. Milstein M. L., Musa H., Balbuena D. P., Anumonwo J. M., Auerbach D. S., Furspan P. B., et al. . (2012). Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. Proc. Natl. Acad. Sci. U.S.A. 109, E2134–E2143. 10.1073/pnas.1109370109 - DOI - PMC - PubMed
    1. Noble D., Varghese A., Kohl P., Noble P. (1998). Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes. Can. J. Cardiol. 14, 123–134. - PubMed

LinkOut - more resources