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. 2016;61(24):1844-1854.
doi: 10.1007/s11434-016-1202-z. Epub 2016 Dec 5.

Segregation between the parietal memory network and the default mode network: effects of spatial smoothing and model order in ICA

Yang Hu  1 , Jijun Wang  2 , Chunbo Li  2 , Yin-Shan Wang  1 , Zhi Yang  3 , Xi-Nian Zuo  4
Affiliations

Segregation between the parietal memory network and the default mode network: effects of spatial smoothing and model order in ICA

Yang Hu et al. Sci Bull (Beijing). 2016.

Abstract

A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network (DMN), its function has been associated with memory processing, and it has been referred to as the parietal memory network (PMN). Independent component analysis (ICA) is the most common data-driven method used to extract PMN and DMN simultaneously. However, the effects of data preprocessing and parameter determination in ICA on PMN-DMN segregation are completely unknown. Here, we employ three typical algorithms of group ICA to assess how spatial smoothing and model order influence the degree of PMN-DMN segregation. Our findings indicate that PMN and DMN can only be stably separated using a combination of low-level spatial smoothing and high model order across the three ICA algorithms. We thus argue for more considerations on parametric settings for interpreting DMN data.

Keywords: Default mode network; Independent component analysis; Model order; Parietal memory network; Resting-state fMRI; Spatial smoothing.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
PMN and DMN templates with corresponding anchor points. PMN template in red and anchor points in blue, located in precuneus and posterior cingulate. DMN template in yellow and anchor points in blue, located in posterior cingulate and paracingulate gyrus. Anterior DMN template in green and anchor point in blue, located in paracingulate gyrus. Posterior DMN template in pink and anchor point in blue, located in posterior cingulate
Fig. 2
Fig. 2
Flow chart presenting procedures for selecting independent components (ICs) corresponding to PMN and DMN
Fig. 3
Fig. 3
The selected IC maps representing PMN and DMN in four combinations of spatial smoothing levels and model orders across three algorithms. A red border means that the RSN is identified as posterior DMN
See this image and copyright information in PMC

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