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Review
. 2017;16(10):859-870.
doi: 10.2174/1566524017666170109123238.

Sumoylation in Lens Differentiation and Pathogenesis

J-W Xiang, Z-G Chen, L Gong, Y Xiao, W-J Qing, L Wang, X-H Hu, Z-X Huang, R-L Qi, T-H Yang, A-P Arrigo, L Zhang, X-C Tang, S Huang, F-Y Liu, Z-W Luo, Y-F Liu, Q Sun, J Gigantelli, Y-Z Liu, D W-C Li  1
Affiliations
Review

Sumoylation in Lens Differentiation and Pathogenesis

J-W Xiang et al. Curr Mol Med. 2017.

Abstract

Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.

Keywords: Lens; cataractogenesis; differentiation; pathogenesis; sumoylation.

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