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Meta-Analysis
. 2017 Jan 9:7:40320.
doi: 10.1038/srep40320.

Prevalence of antepartum hemorrhage in women with placenta previa: a systematic review and meta-analysis

Dazhi Fan  1   2 , Song Wu  3 , Li Liu  2   4 , Qing Xia  2 , Wen Wang  1 , Xiaoling Guo  1 , Zhengping Liu  1
Affiliations
Meta-Analysis

Prevalence of antepartum hemorrhage in women with placenta previa: a systematic review and meta-analysis

Dazhi Fan et al. Sci Rep. .

Abstract

Antepartum hemorrhage (APH) is an important cause of perinatal mortality and maternal morbidity in pregnant women with placenta previa in the world. However, the epidemiological characteristics are not completely understood. We performed an initial systematic review and meta-analysis to assess the prevalence of APH in pregnant women with placenta previa. It was totally performed following the Preferred Reporting Items for Systematic reviews and Meta-Analysis statement. PubMed, Elsevier Science Direct, and the Cochrane Library were searched before April 2016. A meta-analysis with a random-effects model based on a proportions approach was performed to determine the prevalence. Stratified analyses, meta-regression method, and sensitivity analysis were utilized to analyze the heterogeneity. A total of 29 articles were included. The pooled overall prevalence of APH among pregnant women with placenta previa was 51.6% (95% CI 42.7-60.6) in a heterogeneous set of studies (I2 = 97.9). Correlation analysis found that there was a positive correlation between prevalence and percentage of multiparous (r = 0.534, P = 0.027) and a negative correlation between prevalence and survey year (r = -0.400, P = 0.031). In conclusion, the prevalence of APH was a high condition among pregnant women with placenta previa.

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Figures

Figure 1
Figure 1. PRISMA flowchart showing the study selection process.
Figure 2
Figure 2. Forest plot of pooled estimated prevalence of APH with 95% CI.
Figure 3
Figure 3. Sensitivity analysis for individual studies on the summary effect.
Figure 4
Figure 4. Funnel plot of the 29 studies included in the meta-analysis.
Figure 5
Figure 5
The correlation between APH prevalence and percentage of multiparous (A) and survey year (B).
See this image and copyright information in PMC

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