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. 2017 Nov;22(7):661-666.
doi: 10.1080/1354750X.2016.1276625. Epub 2017 Mar 22.

H19 non-coding RNA in urine cells detects urothelial carcinoma: a pilot study

Ilan Gielchinsky  1 , Michal Gilon  2 , Rasha Abu-Lail  2 , Imad Matouk  2 , Avraham Hochberg  2 , Ofer N Gofrit  1 , Iddo Z Ben-Dov  3
Affiliations

H19 non-coding RNA in urine cells detects urothelial carcinoma: a pilot study

Ilan Gielchinsky et al. Biomarkers. 2017 Nov.

Abstract

Context: Urothelial carcinoma (UC) is common and highly recurrent. Diagnosis and follow-up involve invasive cystoscopies.

Objective: To evaluate H19 RNA in urine cells as diagnostic tool for UC.

Materials and methods: RT-PCR analysis of urine samples from healthy volunteers and UC patients.

Results: H19 RNA was unequivocally detected in the urine of 90.5% of patients and 25.9% of controls. H19 copies were three orders of magnitude higher in patients. Receiver operating characteristic analysis showed an area under the curve of 0.933.

Conclusions: This pilot study shows that urinary cell H19 is a highly sensitive test for UC and pending verification could transform patient management.

Keywords: Non-coding RNA; bladder cancer; diagnostic biomarkers; urine biomarkers.

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