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. 2017 May;72(5):481-484.
doi: 10.1136/thoraxjnl-2016-209598. Epub 2017 Jan 9.

Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development

Yina Du  1 , Joseph A Kitzmiller  1 , Anusha Sridharan  1 , Anne K Perl  1 , James P Bridges  1 , Ravi S Misra  2 , Gloria S Pryhuber  2 , Thomas J Mariani  2 , Soumyaroop Bhattacharya  2 , Minzhe Guo  1 , S Steven Potter  3 , Phillip Dexheimer  4 , Bruce Aronow  4 , Alan H Jobe  1 , Jeffrey A Whitsett  1 , Yan Xu  1   4
Affiliations

Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development

Yina Du et al. Thorax. 2017 May.

Abstract

'LungGENS', our previously developed web tool for mapping single-cell gene expression in the developing lung, has been well received by the pulmonary research community. With continued support from the 'LungMAP' consortium, we extended the scope of the LungGENS database to accommodate transcriptomics data from pulmonary tissues and cells from human and mouse at different stages of lung development. Lung Gene Expression Analysis (LGEA) web portal is an extended version of LungGENS useful for the analysis, display and interpretation of gene expression patterns obtained from single cells, sorted cell populations and whole lung tissues. The LGEA web portal is freely available at http://research.cchmc.org/pbge/lunggens/mainportal.html.

Keywords: Airway Epithelium; Surfactant protein; Systemic disease and lungs; TTF-1.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
(A) The home page of the Lung Gene Expression Analysis (LGEA) web portal provides access to data and to query results. Two integrative analytical tools ‘Gene At Glance’ (B) and ‘SigComparison’ (C) in LGEA are shown. LungSortedCells and LungDTC query functions are shown (D and E).
See this image and copyright information in PMC

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