The Generation R Study: design and cohort update 2017

Marjolein N Kooijman¹, Claudia J Kruithof¹, Cornelia M van Duijn², Liesbeth Duijts^{3

4

5}, Oscar H Franco², Marinus H van IJzendoorn^{6

7}, Johan C de Jongste^{3

4}, Caroline C W Klaver⁸, Aad van der Lugt⁹, Johan P Mackenbach¹⁰, Henriëtte A Moll³, Robin P Peeters¹¹, Hein Raat¹⁰, Edmond H H M Rings³, Fernando Rivadeneira¹¹, Marc P van der Schroeff¹², Eric A P Steegers¹³, Henning Tiemeier¹⁴, André G Uitterlinden¹¹, Frank C Verhulst¹⁴, Eppo Wolvius¹⁵, Janine F Felix^{1

2

3}, Vincent W V Jaddoe^{16

17

18}

Affiliations

¹ The Generation R Study Group (NA-2915), Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
² Department of Epidemiology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
³ Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁴ Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁵ Division of Neonatology, Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁶ Center for Child and Family Studies, Leiden University, Leiden, The Netherlands.
⁷ Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
⁸ Department of Ophthalmology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁹ Department of Radiology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁰ Department of Public Health, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹¹ Department of Internal Medicine, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹² Department of Otolaryngology, Head and Neck Surgery, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹³ Department of Obstetrics and Gynecology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁴ Department of Child and Adolescent Psychiatry, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁵ Department of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁶ The Generation R Study Group (NA-2915), Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.
¹⁷ Department of Epidemiology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.
¹⁸ Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.

PMID: 28070760
PMCID: PMC5233749
DOI: 10.1007/s10654-016-0224-9

The Generation R Study: design and cohort update 2017

Marjolein N Kooijman et al. Eur J Epidemiol. 2016 Dec.

. 2016 Dec;31(12):1243-1264.

doi: 10.1007/s10654-016-0224-9. Epub 2017 Jan 9.

Authors

Affiliations

¹ The Generation R Study Group (NA-2915), Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
² Department of Epidemiology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
³ Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁴ Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁵ Division of Neonatology, Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁶ Center for Child and Family Studies, Leiden University, Leiden, The Netherlands.
⁷ Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
⁸ Department of Ophthalmology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
⁹ Department of Radiology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁰ Department of Public Health, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹¹ Department of Internal Medicine, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹² Department of Otolaryngology, Head and Neck Surgery, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹³ Department of Obstetrics and Gynecology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁴ Department of Child and Adolescent Psychiatry, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁵ Department of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
¹⁶ The Generation R Study Group (NA-2915), Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.
¹⁷ Department of Epidemiology, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.
¹⁸ Department of Pediatrics, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl.

PMID: 28070760
PMCID: PMC5233749
DOI: 10.1007/s10654-016-0224-9

Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

Keywords: Adolescence; Child; Cohort study; Epidemiology; Pregnancy.

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Figures

**Fig. 1**
Enrolment and follow-up rates in the Generation R Study

**Fig. 2**
Response to the questionnaires and visits in the Generation R Study

See this image and copyright information in PMC

References

1. Hofman A, Jaddoe VW, Mackenbach JP, Moll HA, Snijders RF, Steegers EA, et al. Growth, development and health from early fetal life until young adulthood: the Generation R Study. Paediatr Perinat Epidemiol. 2004;18(1):61–72. doi: 10.1111/j.1365-3016.2003.00521.x. - DOI - PubMed
1. Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, et al. The Generation R Study: design and cohort update until the age of 4 years. Eur J Epidemiol. 2008;23(12):801–811. doi: 10.1007/s10654-008-9309-4. - DOI - PubMed
1. Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, et al. The Generation R Study: design and cohort update 2010. Eur J Epidemiol. 2010;25(11):823–841. doi: 10.1007/s10654-010-9516-7. - DOI - PMC - PubMed
1. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van IJzendoorn MH, de Jongste JC, et al. The Generation R Study: design and cohort update 2012. Eur J Epidemiol. 2012;27(9):739–756. doi: 10.1007/s10654-012-9735-1. - DOI - PubMed
1. Jaddoe VW, Bakker R, van Duijn CM, van der Heijden AJ, Lindemans J, Mackenbach JP, et al. The Generation R Study biobank: a resource for epidemiological studies in children and their parents. Eur J Epidemiol. 2007;22(12):917–923. doi: 10.1007/s10654-007-9209-z. - DOI - PMC - PubMed

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The Generation R Study: design and cohort update 2017

Affiliations

The Generation R Study: design and cohort update 2017

Authors

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous