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. 2017 Feb 3;82(3):1412-1419.
doi: 10.1021/acs.joc.6b02582. Epub 2017 Jan 19.

Enantioselective Organocatalyzed Vinylogous Michael Reactions of 3-Alkylidene Oxindoles with Enals

Junjun Feng  1 , Xin Li  1   2 , Jin-Pei Cheng  1   2
Affiliations

Enantioselective Organocatalyzed Vinylogous Michael Reactions of 3-Alkylidene Oxindoles with Enals

Junjun Feng et al. J Org Chem. .

Abstract

An efficient asymmetric vinylogous Michael addition of 3-alkylidene oxindoles and enals has been achieved using a chiral TBS-protected diphenylprolinol catalyst. The γ-substituted alkylidene oxindoles obtained bear a chiral tertiary center and are afforded in moderate to good yields and good to excellent enantioselectivities.

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