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Comment
. 2017 Jan 9;31(1):1-2.
doi: 10.1016/j.ccell.2016.12.008.

Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer

Michelle Monje  1
Affiliations
Free article
Comment

Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer

Michelle Monje. Cancer Cell. .
Free article

Abstract

The nervous system is emerging as a regulator of malignancy. In this issue of Cancer Cell, Hayakawa et al. demonstrate a feedforward signaling loop in which tumor-derived nerve growth factor promotes enteric tumor innervation, and recruited nerves drive cancer growth through acetylcholine-regulated Wnt signaling and stimulation of further NGF release.

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Comment in

  • Of nerves and stomach cancer.
    Ferrarelli LK. Ferrarelli LK. Sci Signal. 2017 Mar 7;10(469):eaan0914. doi: 10.1126/scisignal.aan0914. Sci Signal. 2017. PMID: 28270552

Comment on

  • Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
    Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC. Hayakawa Y, et al. Cancer Cell. 2017 Jan 9;31(1):21-34. doi: 10.1016/j.ccell.2016.11.005. Epub 2016 Dec 15. Cancer Cell. 2017. PMID: 27989802 Free PMC article.

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