Comment
doi: 10.1126/scisignal.aam7242.
New connections: NHERF gates activity
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- PMID: 28074011
- DOI: 10.1126/scisignal.aam7242
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Comment
New connections: NHERF gates activity
Sci Signal.
.
Abstract
The NHERF molecular adaptors serve as gates for TRPC4 and TRPC5 regulation by diacylglycerol and recognition of CFTR by the quality control checkpoint.
Copyright © 2017, American Association for the Advancement of Science.
Comment on
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A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint.Sci Signal. 2015 May 19;8(377):ra48. doi: 10.1126/scisignal.aaa1580. Sci Signal. 2015. PMID: 25990958
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Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol.Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E37-E46. doi: 10.1073/pnas.1612263114. Epub 2016 Dec 19. Proc Natl Acad Sci U S A. 2017. PMID: 27994151 Free PMC article.
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