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Comment
. 2016 Dec;111(12):2130-2131.
doi: 10.1111/add.13551.

The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?

Susan B Brogly  1 , Kelley Saia  2 , Sonia Hernández-Diaz  3 , Martha Werler  4 , Paola Sebastiani  5
Affiliations
Comment

The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?

Susan B Brogly et al. Addiction. 2016 Dec.

Abstract

Preferential treatment of high-risk opioid-dependent pregnant women with methadone limits evidence of the comparative safety of buprenorphine versus methadone on infant outcomes. Adjustment for maternal characteristics that affect both treatment choices and birth outcomes is necessary to provide valid estimates of the effect of prenatal opioid agonist therapy exposure.

Keywords: Birth outcomes; buprenorphine; infants; methadone; neonatal abstinence syndrome; pregnancy.

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Conflict of interest statement

Declaration of interests

None.

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References

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