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. 2017 Jan 1;215(1):52-55.
doi: 10.1093/infdis/jiw501. Epub 2016 Oct 25.

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers

Kristen K Pierce  1 , Stephen S Whitehead  2 , Beth D Kirkpatrick  1 , Palmtama L Grier  3 , Adrienne Jarvis  1 , Heather Kenney  2 , Marya P Carmolli  1 , Cynthia Reynolds  1 , Cecilia M Tibery  3 , Janece Lovchik  3 , Anna Janiak  3 , Catherine J Luke  2 , Anna P Durbin  3 , Alexander G Pletnev  2
Affiliations

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers

Kristen K Pierce et al. J Infect Dis. .

Abstract

West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.

Keywords: West Nile virus; flavivirus; vaccine.

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