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. 2017 Mar 1;65(3):300-305.
doi: 10.1248/cpb.c16-00881. Epub 2017 Jan 12.

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc  1 , Pham Thi Mai Huong, Nguyen Van Thanh, Nguyen Thi Phuong Chi, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh
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Free article

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc et al. Chem Pharm Bull (Tokyo). .
Free article

Abstract

Twelve steroids, including five new compounds 1-5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against three human cancer cell lines, lung carcinoma (A-549), cervical adenocarcinoma (HeLa), and pancreatic epithelioid carcinoma (PANC-1), were evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays. Among isolated compounds, 10 exhibited potent cytotoxic effects on all three tested cell lines with IC50 values of 3.64±0.18, 19.34±0.42, and 1.78±0.69 µM, respectively.

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