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. 2017 Mar 1;65(3):300-305.
doi: 10.1248/cpb.c16-00881. Epub 2017 Jan 12.

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc  1 , Pham Thi Mai Huong, Nguyen Van Thanh, Nguyen Thi Phuong Chi, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh
Affiliations
Free article

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta

Ninh Thi Ngoc et al. Chem Pharm Bull (Tokyo). .
Free article

Abstract

Twelve steroids, including five new compounds 1-5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against three human cancer cell lines, lung carcinoma (A-549), cervical adenocarcinoma (HeLa), and pancreatic epithelioid carcinoma (PANC-1), were evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays. Among isolated compounds, 10 exhibited potent cytotoxic effects on all three tested cell lines with IC50 values of 3.64±0.18, 19.34±0.42, and 1.78±0.69 µM, respectively.

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