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Review
. 2017 Jan 6:13:3.
doi: 10.1186/s13223-016-0173-6. eCollection 2017.

Asthma and the microbiome: defining the critical window in early life

Leah T Stiemsma  1 , Stuart E Turvey  2
Affiliations
Review

Asthma and the microbiome: defining the critical window in early life

Leah T Stiemsma et al. Allergy Asthma Clin Immunol. .

Abstract

Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes that changing environmental exposures play a significant role in the etiology of this disease. The microflora hypothesis suggests that early life exposures are disrupting the composition of the microbiota and consequently, promoting immune dysregulation in the form of hypersensitivity disorders. Animal model research supports a role of the microbiota in asthma and atopic disease development. Further, these model systems have identified an early life critical window, during which gut microbial dysbiosis is most influential in promoting hypersensitivity disorders. Until recently this critical window had not been characterized in humans, but now studies suggest that the ideal time to use microbes as preventative treatments or diagnostics for asthma in humans is within the first 100 days of life. This review outlines the major mouse-model and human studies leading to characterization of the early life critical window, emphasizing studies analyzing the intestinal and airway microbiotas in asthma and atopic disease. This research has promising future implications regarding childhood immune health, as ultimately it may be possible to therapeutically administer specific microbes in early life to prevent the development of asthma in children.

Keywords: Asthma; Critical window; Early life; Hygiene hypothesis; Microbiota; Microflora hypothesis.

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Figures

Fig. 1
Fig. 1
Defining the critical window of early life in a mice and b humans
See this image and copyright information in PMC

References

    1. Lyons A, O’Mahony D, O’Brien F, MacSharry J, Sheil B, Ceddia M, Russell WM, Forsythe P, Bienenstock J, Kiely B, et al. Bacterial strain-specific induction of Foxp3 + T regulatory cells is protective in murine allergy models. Clin Exp Allergy. 2010;40(5):811–819. - PubMed
    1. Russell SL, Gold MJ, Willing BP, Thorson L, McNagny KM, Finlay BB. Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma. Gut Microbes. 2013;4(2):158–164. doi: 10.4161/gmic.23567. - DOI - PMC - PubMed
    1. Russell SL, Gold MJ, Reynolds LA, Willing BP, Dimitriu P, Thorson L, Redpath SA, Perona-Wright G, Blanchet MR, Mohn WW, Finlay BB. Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. J Allergy Clin Immunol. 2015;135(1):100–109. doi: 10.1016/j.jaci.2014.06.027. - DOI - PubMed
    1. Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015;7(307):307ra152. doi: 10.1126/scitranslmed.aab2271. - DOI - PubMed
    1. Stiemsma L, Arrieta MC, Dimitriu P, Cheng J, Thorson L, Lefebvre D, Azad MB, Subbarao P, Mandhane P, Becker A, et al. Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool-age asthma. Clin Sci (Lond). 2016;130(23):2199–2207. doi: 10.1042/CS20160349. - DOI - PubMed