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Review
. 2016 Dec 25;8(4):169-174.
eCollection 2016.

Proton pump inhibitor-induced hypomagnesaemia and hypocalcaemia: case review

Jonathan Sivakumar  1
Affiliations
Review

Proton pump inhibitor-induced hypomagnesaemia and hypocalcaemia: case review

Jonathan Sivakumar. Int J Physiol Pathophysiol Pharmacol. .

Abstract

Proton pump inhibitor (PPI)-induced hypomagnesaemia is a rare but serious adverse effect of a widely prescribed medication. It has become an increasingly recognised complication since 2006, with the U.S. Food and Drug Administration issuing a warning for this risk with regards to long-term PPI use. We present the case of PPI-associated hypomagnesaemia and hypocalcaemia. A 91 year old male presented with tetany from severe hypomagnesaemia and hypocalcaemia. This condition occurred in the context of 18 months of PPI use, and resolved following cessation of PPI therapy and the replenishment of magnesium and calcium stores. Monitoring of magnesium, calcium and potassium levels is crucial in patients prescribed PPIs long-term; especially the elderly patient.

Keywords: PPI; hypomagnesemia.

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