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. 2016 Dec;7(6):1011-1016.
doi: 10.21037/jgo.2016.09.11.

Gastrointestinal lymphoma in Western Algeria: pattern of distribution and histological subtypes (retrospective study)

Soumia Zeggai  1 , Noria Harir  1 , Abdenacer Tou  2 , Miloud Medjamia  3 , Khaira Guenaoui  1
Affiliations

Gastrointestinal lymphoma in Western Algeria: pattern of distribution and histological subtypes (retrospective study)

Soumia Zeggai et al. J Gastrointest Oncol. 2016 Dec.

Abstract

Background: Primary gastrointestinal (GI) lymphomas (GIL) are uncommon diseases that can involve the whole GI tract. Considerable variation exists in the literature with respect to incidence of the various histological subtypes and sites of involvement. This study was undertaken to establish the anatomic distribution, histological subtypes and sites of GI lymphomas of patients from Western Algeria.

Methods: The case records of 58 consecutive patients with GIL diagnosed at the Pathologies Departments of Algerian west region (the Military Hospital of Oran city and the Central University Hospital of Sidi Bel Abbes city) from January 2006 to December 2013 were retrospectively evaluated for epidemiology and histopathology report. All lymphomas were reclassified according to the WHO 2008 classification.

Results: A total of 58 patients (39 male, 19 female) with mean age of 61 years and a range of 20-89 years were included in this study. Stomach was the most common site involved (70.7%). The commonest histological subtype was mucosa-associated lymphoid tissue (MALT) B cell lymphoma (46.6%), followed by diffuse large B-cell lymphomas (DLBCL) (43.1%).The frequency of Helicobacter pylori (HP) positivity differ between gastric and intestinal location P=0.003 and correlates with the histological type P=0.01.

Conclusions: This retrospective study of patients with GI lymphoma from Western Algeria illustrates the pattern of distribution of various common and rare histological subtypes. More studies are necessary to find a potential cause, risk factor or genetic mutation that can explain these specific characteristics of GIL.

Keywords: Gastrointestinal lymphomas (GIL); Western Algeria; anatomic distribution; histological subtypes.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

References

    1. Huh J. Epidemiologic overview of malignant lymphoma. Korean J Hematol 2012;47:92-104. 10.5045/kjh.2012.47.2.92 - DOI - PMC - PubMed
    1. Jemal A, Tiwari RC, Murray T, et al. Cancer statistics, 2004. CA Cancer J Clin 2004;54:8-29. 10.3322/canjclin.54.1.8 - DOI - PubMed
    1. Zucca E, Roggero E, Bertoni F, et al. Primary extranodal non-Hodgkin's lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol 1997;8:727-37. 10.1023/A:1008282818705 - DOI - PubMed
    1. Crump M, Gospodarowicz M, Shepherd FA. Lymphoma of the gastrointestinal tract. Semin Oncol 1999;26:324-37. - PubMed
    1. Bellesi G, Alterini R, Messori A, et al. Combined surgery and chemotherapy for the treatment of primary gastrointestinal intermediate- or high-grade non-Hodgkin's lymphomas. Br J Cancer 1989;60:244-8. 10.1038/bjc.1989.262 - DOI - PMC - PubMed