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Review
. 2016 Dec;5(6):935-950.
doi: 10.21037/tau.2016.10.03.

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Ashok Agarwal  1 , Ahmad Majzoub  2 , Sandro C Esteves  3 , Edmund Ko  4 , Ranjith Ramasamy  5 , Armand Zini  6
Affiliations
Review

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Ashok Agarwal et al. Transl Androl Urol. 2016 Dec.

Abstract

Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. This review delivers practice based recommendations on commonly encountered scenarios in the clinic. An illustrative description of the different SDF measurement techniques is presented. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates. High SDF is also linked with recurrent spontaneous abortion (RSA) and can influence outcomes of different assisted reproductive techniques. Several studies have shown some benefit in using testicular sperm rather than ejaculated sperm in men with high SDF, oligozoospermia or recurrent in vitro fertilization (IVF) failure. Infertile men with evidence of exposure to pollutants can benefit from sperm DNA testing as it can help reinforce the importance of lifestyle modification (e.g., cessation of cigarette smoking, antioxidant therapy), predict fertility and monitor the patient's response to intervention.

Keywords: Sperm DNA fragmentation (SDF); assisted reproductive technology (ART); male infertility; unexplained infertility; varicocele.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Comment in

References

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