Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jan;13(1):71-76.
doi: 10.3988/jcn.2017.13.1.71.

Migraine Susceptibility Genes in Han Chinese of Fujian Province

Qi Fang Lin  1 , Zi Chun Chen  2 , Xian Guo Fu  3 , Jing Yang  3 , Luo Yuan Cao  3 , Long Teng Yao  1 , Yong Tong Xin  1 , Gen Bin Huang  4
Affiliations

Migraine Susceptibility Genes in Han Chinese of Fujian Province

Qi Fang Lin et al. J Clin Neurol. 2017 Jan.

Abstract

Background and purpose: Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population.

Methods: This was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction-restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients.

Results: The frequencies of the five SNPs did not differ between patients with migraine and healthy non migraine controls. However, subgroup analysis indicated certain SNPs were more strongly associated with migraine with aura or migraine without aura than with controls. The CT genotype of rs4379368 was more common in migraine patients with aura (75%) than in migraine patients without aura (47.9%) and controls (48.5%) (p<0.05), and the TT genotype of rs10504861 was more common in migraine patients with aura than in controls (8.3% vs. 0.5%) (p<0.05). Meanwhile, the CC genotype of rs12134493 was less common in migraine patients without aura than in controls (80.6% vs. 88%) (p<0.05).

Conclusions: Our findings suggest that the rs4379368 and rs10504861 SNPs are markers for susceptibility to migraine with aura and that rs12134493 is a marker for the risk of migraine without aura in this Han population. Future studies should further explore if these associations vary by ethnicity.

Keywords: aura; genotype; migraine; rs10504861; rs12134493; rs4379368; single-nucleotide polymorphism.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial conflict of interest.

References

    1. Stovner LJ, Hagen K. Prevalence, burden, and cost of headache disorders. Curr Opin Neurol. 2006;19:281–285. - PubMed
    1. Bigal ME, Lipton RB. The epidemiology, burden, and comorbidities of migraine. Neurol Clin. 2009;27:321–334. - PubMed
    1. Paemeleire K, Louis P, Magis D, Vandenheede M, Versijpt J, Vandersmissen B, et al. Diagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society. Acta Neurol Belg. 2015;115:1–17. - PubMed
    1. Ulrich V, Gervil M, Kyvik KO, Olesen J, Russell MB. Evidence of a genetic factor in migraine with aura: a population-based Danish twin study. Ann Neurol. 1999;45:242–246. - PubMed
    1. Lemos C, Castro MJ, Barros J, Sequeiros J, Pereira-Monteiro J, Mendon-a D, et al. Familial clustering of migraine: further evidence from a Portuguese study. Headache. 2009;49:404–411. - PubMed

LinkOut - more resources