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Review
. 2017 Mar;36(3):372-374.
doi: 10.1097/ICO.0000000000001139.

Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma

Laurel T Tainsh  1 , Patrick A Coady, John H Sinard, Natalia Neparidze, Seth W Meskin, Ron A Adelman, Jessica Chow
Affiliations
Review

Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma

Laurel T Tainsh et al. Cornea. 2017 Mar.

Abstract

Purpose: To report a case of asymmetric deep stromal keratopathy in a patient with multiple myeloma.

Methods: Case report and literature review.

Results: An 85-year-old woman was found to have progressive visually significant left-sided deep stromal opacity in the setting of monoclonal gammopathy. Hematologic workup resulted in a diagnosis of IgG kappa multiple myeloma. Histopathology was significant for semicrystalline deposits in the posterior stroma. The patient's visual acuity improved to 20/50 7 months after penetrating keratoplasty. A similar deep stromal lesion appeared in the right eye 2 years after initial presentation.

Conclusions: We present an unusual case of paraproteinemic keratopathy with a uniquely asymmetric presentation that resulted in a diagnosis of multiple myeloma.

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